Triterpene acids from Poria cocos and their anti-tumor-promoting effects.

Abstract

The structures of six new lanostane-type triterpene acids isolated from the epidermis of the sclerotia of Poria cocos were established to be 15alpha-hydroxydehydrotumulosic acid (5), 16alpha,25-dihydroxydehydroeburicoic acid (9), 5alpha,8alpha-peroxydehydrotumulosic acid (10), 25-hydroxyporicoic acid H (11), 16-deoxyporicoic acid B (12), and poricoic acid CM (16) on the basis of spectroscopic methods. On evaluation of these six and 11 other known triterpene acids isolated from the sclerotium, 1-4, 6-8, 13-15, and 17, against the Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, all of the compounds except for 1, 3, 4, and 8 exhibited inhibitory effects with IC50 values of 195-340 mol ratio/32 pmol TPA. Compound 12 and poricoic acid C (13) exhibited inhibitory effects on skin tumor promotion in an in vivo two-stage carcinogenesis test using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter.

• Authors: Toshihiro Akihisa, Yuji Nakamura, Harukuni Tokuda, Emiko Uchiyama, Takashi Suzuki, Yumiko Kimura, Kazuo Uchikura, Hoyoku Nishino
• Journal: Journal of natural products (J Nat Prod) Vol. 70 Issue 6 Pg. 948-53 (Jun 2007) ISSN: 0163-3864 [Print] United States
• PMID: 17488130 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticarcinogenic Agents
• Antigens, Viral
• Epstein-Barr virus early antigen
• Triterpenes
• 9,10-Dimethyl-1,2-benzanthracene
• Tetradecanoylphorbol Acetate

Topics

• 9,10-Dimethyl-1,2-benzanthracene (pharmacology)
• Anticarcinogenic Agents (chemistry, isolation & purification, pharmacology)
• Antigens, Viral (drug effects)
• Humans
• Molecular Structure
• Plants, Medicinal (chemistry)
• Polyporaceae (chemistry)
• Tetradecanoylphorbol Acetate (pharmacology)
• Triterpenes (chemistry, isolation & purification, pharmacology)