Syntenin: a novel PDZ domain-containing scaffolding protein associated with human melanoma metastasis.

Abstract

Syntenin is overexpressed in multiple human cancers and is newly recognized as a novel regulator in melanoma metastasis. It functions as a scaffolding protein, via its two PDZ domains interacting with multiple transmembrane and cytoplasmic partners to regulate many of the major signaling pathways involved in various cellular processes, such as cell surface receptor clustering, protein trafficking, cytoskeleton remodeling, and activation of transcription factor, and results in the increased abilities for tumor cell growth, adhesion, angiogenesis, invasion and metastasis. The present article attempts to review the structure and functions of syntenin by summarizing our current knowledge on the interacting partners and diverse signaling pathways related to syntenin, and highlight the importance of syntenin as a new potential therapeutic target for the aggressive human melanoma.

• Authors: Jian-Bo Yang, James B McCarthy
• Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences (Zhong Nan Da Xue Xue Bao Yi Xue Ban) Vol. 32 Issue 2 Pg. 204-12 (Apr 2007) ISSN: 1672-7347 [Print] China
• PMID: 17478924 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)

Chemical References

• Biomarkers, Tumor
• Syntenins

Topics

• Animals
• Biomarkers, Tumor (genetics, metabolism)
• Humans
• Melanoma (genetics, metabolism, pathology)
• Neoplasm Metastasis
• PDZ Domains (genetics)
• Signal Transduction
• Syntenins (chemistry, genetics, metabolism)