Antitumor and antimetastatic effects of betulonic acid amides in mice with transplantable lewis carcinoma.

Abstract

We studied the effects of four synthetic amides of betulonic acid containing amino acid fragments (d,l-alpha-alanine, beta-alanine, and their methyl esters) on the rate of growth and metastatic dissemination of transplantable Lewis lung carcinoma in C57Bl/6 mice. The test compounds were administered intragastrically in a single dose of 500 mg/kg. 3-[-oxo-20(29)-lupen-28-oilamino]-propionic acid suppressed primary tumor growth (by 26%) and decreased the number of lung metastases (by more than 2 times). Antitumor and antimetastatic activity of triterpenoids decreased after methylation of the amino acid fragment in betulonic acid.

• Authors: I V Sorokina, T G Tolstikova, N A Zhukova, N I Petrenko, N V Uzenkova, E E Shul'ts, N A Popova
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 142 Issue 1 Pg. 69-72 (Jul 2006) ISSN: 0007-4888 [Print] United States
• PMID: 17369906 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• (3-oxo-20(29)-lupene-28-oyl)-3-aminopropionamide
• Antineoplastic Agents
• Oleanolic Acid
• Alanine

Topics

• Alanine (chemistry)
• Animals
• Antineoplastic Agents (chemistry, therapeutic use)
• Carcinoma, Lewis Lung (drug therapy, pathology)
• Male
• Mice
• Mice, Inbred C57BL
• Neoplasm Metastasis (pathology, prevention & control)
• Oleanolic Acid (analogs & derivatives, chemistry, therapeutic use)