Abstract | BACKGROUND AND PURPOSE: EXPERIMENTAL APPROACH: KEY RESULTS: Expression of morphine-induced locomotor sensitization was abolished after combined treatment with amisulpride (20 mg x kg(-1), i.p.) and RB101 (80 mg x kg(-1), i.p.), whereas these drugs were not effective when used alone. We then compared these results with the effects of amisulpride combined with buprenorphine (0.1 mg x kg(-1), i.p.) or methadone (2.5 mg x kg(-1), i.p.) upon morphine-induced behavioral sensitization. Whereas the combination of amisulpride and buprenorphine partially blocked the expression of morphine sensitization, amisulpride+methadone was not effective in this paradigm. CONCLUSIONS AND IMPLICATIONS: The combination of amisulpride+RB101 appears to be very efficient in blocking the expression of morphine-induced behavioral sensitization. This could reflect a reinstatement of a balance between the function of the dopamine and opioid systems and could represent a new approach in maintenance treatments for opiate addiction.
|
Authors | L Cordonnier, M Sanchez, B P Roques, F Noble |
Journal | British journal of pharmacology
(Br J Pharmacol)
Vol. 151
Issue 1
Pg. 94-102
(May 2007)
ISSN: 0007-1188 [Print] England |
PMID | 17351659
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Disulfides
- RB 101
- Buprenorphine
- Phenylalanine
- Morphine
- Sulpiride
- Amisulpride
- Methadone
|
Topics |
- Amisulpride
- Animals
- Behavior, Animal
(drug effects)
- Buprenorphine
(pharmacology)
- Disulfides
(pharmacology)
- Male
- Methadone
(pharmacology)
- Mice
- Morphine
(antagonists & inhibitors)
- Motor Activity
(drug effects)
- Opioid-Related Disorders
(drug therapy)
- Phenylalanine
(analogs & derivatives, pharmacology)
- Sulpiride
(analogs & derivatives, pharmacology)
|