[Comparative study on treatment of somnipathy in patients with hypertension by traditional Chinese medicine and by estazolam].

Abstract

OBJECTIVE:

To study the efficacy of traditional Chinese medicine (TCM) in treating somnipathy in patients with hypertension, and to observe the change of blood pressure after sleep being improved.

METHODS:

Two hundred and thirty-nine patients with hypertension accompanied somnipathy were randomly assigned to two groups, 123 patients in the treated group were treated with TCM according to syndrome differentiation, and 116 in the control group treated with Estazolam. Changes of blood pressure, scores of sleep dysfunction rating scale (SDRS), Hamilton anxiety rating scale (HAMA) and treatment emergent symptom scale (TESS) before and after treatment were observed.

RESULTS:

TCM showed a significant effect on hypnagogic disturbance, and significantly reduced the scores of insomnia syndromes in early sleep stage, improve the quality of sleep, prolong the sleeping time to fulfill the physiological requirement, the total effective rate being 80.5% (99/123 cases), with the overall effect higher than that (66.4%, 77/116 cases) in the control group (P < 0.05). Along with the improving of sleep, blood pressure, both systolic and diastolic, reduced in both groups, but with the reduction in the treated group superior to that in the control group (P < 0.01), and the rate of reaching target BP (< 140/90 mmHg) in the former was also significantly higher than that in the latter (39.7%, 46/116 cases, P < 0.05). As compared with those in the control group, the occurence of adverse reaction, were less in the treated group (P < 0.05).

CONCLUSION:

TCM has better efficacy in treating somnipathy of hypertension patients than Estazolam. And the improvement of somnipathy is favorable for improving the hypertensive condition of patient.

• Authors: Hai-Cong Li, Yi-Ling Yang, Ming Ma
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 27 Issue 2 Pg. 123-6 (Feb 2007) ISSN: 1003-5370 [Print] China
• PMID: 17342998 (Publication Type: Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Anticonvulsants
• Drugs, Chinese Herbal
• Estazolam

Topics

• Adult
• Aged
• Aged, 80 and over
• Anticonvulsants (therapeutic use)
• Blood Pressure (drug effects)
• Diagnosis, Differential
• Drugs, Chinese Herbal (therapeutic use)
• Estazolam (therapeutic use)
• Female
• Humans
• Hypertension (diagnosis, physiopathology, therapy)
• Male
• Medicine, Chinese Traditional
• Middle Aged
• Phytotherapy
• Sleep Initiation and Maintenance Disorders (diagnosis, physiopathology, therapy)