Abstract | BACKGROUND: OBJECTIVE: METHODS: This was a 6 months prospective trial in 101 patients with painful diabetic neuropathy and minimum score of 2 on a pain intensity scale ranging of 0 to 4. Compliance was assessed with patient interviews and pill counts. Adverse events, early discontinuation or satisfaction with treatment were also evaluated. RESULTS: Patients receiving SSRIs reported greater satisfaction and fewer concerns of the side-effects with their treatment (P<0.05) compared with the patients taking gabapentin. There was statistically significant better mood in the SSRI group (P<0.05). Overall, 43.5% of those taking SSRIs noticed no effect on the pain control, 50% felt better, and 6.5% felt worse. Among the patients taking gabapentin, 51% felt better, 40.5% noticed no effect, and 8.5% felt worse. Finally, on the pill count, more patients on SSRIs (93.5%) than on gabapentin (82.9%) were taking over the 75% of their medication (P<0.05). CONCLUSIONS: The lack of negative effects on quality of life, the better compliance, and the comparable efficiency of SSRIs suggest that these drugs may be considered as alternative to gabapentin in painful diabetic neuropathy.
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Authors | Sotirios Giannopoulos, Maria Kosmidou, Ioannis Sarmas, Sofia Markoula, Sigliti-Henrietta Pelidou, Georgios Lagos, Athanassios P Kyritsis |
Journal | The Clinical journal of pain
(Clin J Pain)
2007 Mar-Apr
Vol. 23
Issue 3
Pg. 267-9
ISSN: 0749-8047 [Print] United States |
PMID | 17314587
(Publication Type: Clinical Trial, Comparative Study, Journal Article)
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Chemical References |
- Amines
- Analgesics
- Anticonvulsants
- Cyclohexanecarboxylic Acids
- Serotonin Uptake Inhibitors
- gamma-Aminobutyric Acid
- Gabapentin
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Topics |
- Adult
- Amines
(therapeutic use)
- Analgesics
(therapeutic use)
- Anticonvulsants
- Chi-Square Distribution
- Cyclohexanecarboxylic Acids
(therapeutic use)
- Diabetic Neuropathies
(drug therapy, psychology)
- Female
- Follow-Up Studies
- Gabapentin
- Humans
- Male
- Middle Aged
- Pain Measurement
- Patient Compliance
- Prospective Studies
- Selective Serotonin Reuptake Inhibitors
(therapeutic use)
- gamma-Aminobutyric Acid
(therapeutic use)
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