[ZNF217 gene was detected in ovarian serous cystadenocarcinoma by fluorescence in situ hybridization].

Abstract

OBJECTIVE:

To investigate amplification of zinc finger protein 217 (ZNF217) gene in ovarian serous cystadenocarcinoma and its clinical significance.

METHODS:

Twenty three specimens of ovarian carcinoma, 10 specimens of ovarian benign tumors and 7 specimens of normal ovaries and two ovarian cancer cell lines, SKOV3 and HO-8910 were examined by fluorescence in situ hybridization (FISH).

RESULTS:

The amplification of ZNF217 was gained in 12 case of ovarian cancers, there was only 1 case in ovarian benign tumor and not amplication in normal ovary.

CONCLUSION:

The amplification of ZNF217 is associated with ovarian cancer. Oncogenes ZNF217 maybe play a role in cell differentiation and indicate poorer survival in patients with ovarian cancer.

• Authors: Mei Zhong, Jing Li, Yan-qing Ding, Lan-lin Song
• Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics (Zhonghua Yi Xue Yi Chuan Xue Za Zhi) Vol. 23 Issue 6 Pg. 665-7 (Dec 2006) ISSN: 1003-9406 [Print] China
• PMID: 17160949 (Publication Type: English Abstract, Journal Article)

Chemical References

• Trans-Activators
• ZNF217 protein, human

Topics

• Adult
• Aged
• Cell Differentiation
• Cell Line, Tumor
• Cystadenocarcinoma, Serous (genetics, pathology)
• Cystadenoma, Serous (genetics, pathology)
• Female
• Gene Amplification
• Humans
• In Situ Hybridization, Fluorescence
• Middle Aged
• Neoplasm Staging
• Ovarian Neoplasms (genetics, pathology)
• Survival Analysis
• Trans-Activators (genetics)