Abstract | OBJECTIVE: To investigate the expression of the profibrotic connective tissue growth factor (CTGF) in relation to severity of intraocular fibrosis and neovascularization in human vitreoretinal disorders for the identification of potential therapeutic targets to prevent fibrosis. METHODS: RESULTS: Multifactorial analysis revealed that only CTGF levels correlated highly significantly with degree of fibrosis in the various vitreoretinal disorders studied (P<.001; R2= 47.7%). Likewise, variation in degree of fibrosis was best predicted by CTGF levels (P<.001). CONCLUSION: The strong correlation between CTGF levels and degree of fibrosis in vitreoretinal disorders suggests that CTGF is an important factor in ocular fibrosis, similar to its role in pathologic fibrosis in other organs. CLINICAL RELEVANCE:
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Authors | Esther J Kuiper, Marc D de Smet, Jan C van Meurs, H Stevie Tan, Michael W T Tanck, Noelynn Oliver, Frans A van Nieuwenhoven, Roel Goldschmeding, Reinier O Schlingemann |
Journal | Archives of ophthalmology (Chicago, Ill. : 1960)
(Arch Ophthalmol)
Vol. 124
Issue 10
Pg. 1457-62
(Oct 2006)
ISSN: 0003-9950 [Print] United States |
PMID | 17030714
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- CCN2 protein, human
- Immediate-Early Proteins
- Intercellular Signaling Peptides and Proteins
- Connective Tissue Growth Factor
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Topics |
- Connective Tissue Growth Factor
- Diabetic Retinopathy
(metabolism, pathology)
- Enzyme-Linked Immunosorbent Assay
- Epiretinal Membrane
(metabolism, pathology)
- Female
- Fibrosis
(metabolism)
- Humans
- Immediate-Early Proteins
(metabolism)
- Intercellular Signaling Peptides and Proteins
(metabolism)
- Male
- Middle Aged
- Retina
(pathology)
- Retinal Perforations
(metabolism, pathology)
- Vitreoretinopathy, Proliferative
(metabolism, pathology)
- Vitreous Body
(metabolism, pathology)
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