Efficacy of ambruticin analogs in a murine model of coccidioidomycosis.

Abstract

Ambruticin S, an antifungal cyclopropyl-pyran acid, showed curative effects against murine coccidioidal infection. Two analogs of this compound with greater in vitro potency were tested against lethal murine Coccidioides infection. Both improved the survival of mice over that of controls; one resulted in near-sterilization of infection.

• Authors: Lisa F Shubitz, John N Galgiani, Zong-Qiang Tian, Ziyang Zhong, Pieter Timmermans, Leonard Katz
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 50 Issue 10 Pg. 3467-9 (Oct 2006) ISSN: 0066-4804 [Print] United States
• PMID: 17005834 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Antifungal Agents
• Pyrans
• ambruticin

Topics

• Animals
• Antifungal Agents (administration & dosage, chemistry, pharmacokinetics, therapeutic use)
• Coccidioides (drug effects)
• Coccidioidomycosis (drug therapy, mortality)
• Disease Models, Animal
• Drug Evaluation, Preclinical
• Female
• Humans
• Lung Diseases, Fungal (drug therapy, mortality)
• Mice
• Mice, Inbred C57BL
• Microbial Sensitivity Tests
• Pyrans (administration & dosage, chemistry, pharmacokinetics, therapeutic use)
• Treatment Outcome