Bacillisporins D and E, new oxyphenalenone dimers from Talaromyces bacillisporus.

Abstract

The oligophenalenone dimer duclauxin and two new analogues, bacillisporins D and E, were isolated from the fungus TALAROMYCES BACILLISPORUS in addition to the previously reported bacillisporins A, B and C. Structures were established by spectroscopic studies. Duclauxin and bacillisporins A, B, C and E were evaluated for cytotoxicity against three human cancer cell lines. Bacillisporin A was strongly active against MCF-7 and NCI-H460 and moderately active against SF-268 while bacillisporins B, C and duclauxin were moderately active against all three cell lines.

• Authors: Tida Dethoup, Leka Manoch, Anake Kijjoa, Maria São Nascimento, Prapawadee Puaparoj, Artur M Silva, Graham Eaton, Werner Herz
• Journal: Planta medica (Planta Med) Vol. 72 Issue 10 Pg. 957-60 (Aug 2006) ISSN: 0032-0943 [Print] Germany
• PMID: 16902873 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Chromones
• Cytotoxins
• Phenalenes
• bacillisporin D
• bacillisporin E
• duclauxin

Topics

• Cell Line, Tumor
• Chromones (chemistry, isolation & purification, toxicity)
• Cytotoxins (chemistry, isolation & purification, toxicity)
• Dimerization
• Humans
• Nuclear Magnetic Resonance, Biomolecular
• Phenalenes (chemistry, isolation & purification, toxicity)
• Talaromyces (chemistry)