[Clinical evaluation of high dose rate intra-cavitary irradiation in the treatment of uterine cervical cancer, combined with pepleomycin suppository in uterine cavity].

Abstract

By means of re-irradiation using pepleomycin suppository in uterine cavity, we attained local control for one patient who had local recurrence in uterine cavity and suffered from uterine fluor in which viable cancer cells were confirmed. We were enlightened by this therapeutic experience, so we attempted combination therapy using pepleomycin suppositories to supplement intra-cavitary irradiation, for the 11 selected patients who were suffering from uterine fluor. We investigated the treatment results in 7 patients of stage III out of 11 patients (of all stages), in comparison with 13 patients of stage III who were treated by irradiation alone. Consequently, these treatment results were approximately equivalent, and the incidence of sigmoid complications could be decreased. Side effects which were followed by the combination therapy were not serious, and so we believe that pepleomycin suppository is a simple method and valuable to supplement radiation therapy of uterine cervical cancer.

• Authors: S Yamanashi, T Abe, S Mochizuki, Y Murakami, N Iida
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 17 Issue 2 Pg. 245-51 (Feb 1990) ISSN: 0385-0684 [Print] Japan
• PMID: 1689133 (Publication Type: English Abstract, Journal Article)

Chemical References

• Suppositories
• Bleomycin
• Peplomycin

Topics

• Administration, Intravaginal
• Adult
• Aged
• Bleomycin (administration & dosage)
• Brachytherapy
• Combined Modality Therapy
• Drug Administration Schedule
• Female
• Humans
• Middle Aged
• Peplomycin
• Radiotherapy Dosage
• Suppositories
• Uterine Cervical Neoplasms (drug therapy, radiotherapy, therapy)