West Nile virus infections projected from blood donor screening data, United States, 2003.

Abstract

National blood donor screening for West Nile virus (WNV) RNA using minipool nucleic acid amplification testing (MP-NAT) was implemented in the United States in July 2003. We compiled national NAT yield data and performed WNV immunoglobulin M (IgM) testing in 1 WNV-epidemic region (North Dakota). State-specific MP-NAT yield, antibody seroprevalence, and the average time RNA is detectable by MP-NAT were used to estimate incident infections in 2003. WNV donor screening yielded 944 confirmed viremic donors. MP-NAT yield peaked in August with >0.5% of donations positive for WNV RNA in 4 states. Peak IgM seroprevalence for North Dakota was 5.2% in late September. The average time viremia is detectable by MP-NAT was 6.9 days (95% confidence interval [CI] 3.0-10.7). An estimated 735,000 (95% CI 322,000-1,147,000) infections occurred in 2003, with 256 (95% CI 112-401) infections per neuroinvasive case. In addition to preventing transfusion-transmitted WNV infection, donor screening can serve as a tool to monitor seasonal incidence in the general population.

• Authors: Michael P Busch, David J Wright, Brian Custer, Leslie H Tobler, Susan L Stramer, Steven H Kleinman, Harry E Prince, Celso Bianco, Gregory Foster, Lyle R Petersen, George Nemo, Simone A Glynn
• Journal: Emerging infectious diseases (Emerg Infect Dis) Vol. 12 Issue 3 Pg. 395-402 (Mar 2006) ISSN: 1080-6040 [Print] United States
• PMID: 16704775 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• RNA, Viral

Topics

• Blood Donors
• Humans
• Incidence
• Mass Screening
• RNA, Viral (blood)
• Seasons
• Sensitivity and Specificity
• Time Factors
• United States (epidemiology)
• West Nile Fever (blood, epidemiology)
• West Nile virus (isolation & purification)