[Relationship between the expression of fragile histidine (FHIT) and the development of vulvar carcinoma].

Abstract

OBJECTIVE:

To explore the relationship between the reduction of FHIT expression of fragile histidine (FHIT) and the development of vulvar carcinoma.

METHODS:

The expression of the FHIT product was detected by immunochemistry in the tissue samples of 20 normal vulvas, 22 vulvar intraepithelial neoplasias (VINs), and 60 primary vulvar carcinomas.

RESULTS:

The expressive rates of FHIT protein in the squamous epithelium of normal vulvas, VIN I - II, VIN II, and noninvasive and invasive vulvar carcinoma were 100% (20/20), 72.7% (8/11), 45.5% (5/11), and 21.7% (13/60) respectively (P<0.05). The expressive rates of FHIT protein in the well differentiated, intermediately differentiated and poorly differentiated invasive vulav carcinoma were 60.0% (9/15), 20.0% (3/15), and 3.3% (1/30) respectively (P<0.05). The expressive rate of the impaired FHIT protein in the invasive vulva carcinoma with lymphnode metastasis (10%) was lower than that without lymphnode metastasis (27.5%).

CONCLUSION:

Abnormal FHIT expression may play an important role in the progression of vulvar carcinoma. The expression of FHIT may provide important information for the prognosis of vulva carcinoma.

• Authors: Yan-Xia Chu, Ai Zheng, Ming-Rong Xi, Jian Zhang
• Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition (Sichuan Da Xue Xue Bao Yi Xue Ban) Vol. 37 Issue 2 Pg. 218-20 (Mar 2006) ISSN: 1672-173X [Print] China
• PMID: 16608079 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Neoplasm Proteins
• fragile histidine triad protein
• Acid Anhydride Hydrolases

Topics

• Acid Anhydride Hydrolases (biosynthesis, genetics)
• Adult
• Aged
• Aged, 80 and over
• Carcinoma in Situ (metabolism)
• Carcinoma, Squamous Cell (metabolism, pathology)
• Female
• Humans
• Middle Aged
• Neoplasm Proteins (biosynthesis, genetics)
• Vulvar Neoplasms (metabolism, pathology)