[7-ethoxycoumarin o-deethylase and fibrosis in chronic liver diseases].

Abstract

In the liver biopsy of 100 patients with chronic liver diseases, the activity of 7-ethoxycoumarin O-deethylase (ECOD) was determined as a parameter of hepatic monooxygenase system and was compared with some markers of fibrosis e.g. collagen peptidase and hydroxyproline. ECOD was significantly different in healthy liver, fatty liver, chronic active hepatitis (CAH) and cirrhosis. The importance of the fibrotic process was shown by the significant correlations between ECOD and the signs of fibrosis in the liver biopsy. A connection between ECOD and the markers of fibrosis was not found. Further research is necessary to clarify this difference.

• Authors: J Truckenbrodt, A Müller, H Kraul, G Machnik, R Volland, M Reinhardt, A Hoffmann
• Journal: Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR (Gastroenterol J) Vol. 51 Issue 1 Pg. 15-7 ( 1991) ISSN: 0863-1743 [Print] Germany
• Vernacular Title: Die 7-Ethoxycoumarin O-Deethylase und der fibrosierende Prozess bei chronischen Lebererkrankungen.
• PMID: 1654926 (Publication Type: English Abstract, Journal Article)

Chemical References

• 7-Alkoxycoumarin O-Dealkylase
• Microbial Collagenase
• Hydroxyproline

Topics

• 7-Alkoxycoumarin O-Dealkylase (analysis)
• Adult
• Biotransformation
• Chronic Disease
• Fatty Liver (enzymology)
• Female
• Hepatitis, Chronic (enzymology)
• Humans
• Hydroxyproline (analysis)
• Liver (enzymology)
• Liver Cirrhosis (enzymology)
• Male
• Microbial Collagenase (analysis)
• Middle Aged