Abstract | OBJECTIVE: METHODS: The clinical presentations, radiologic findings, histologic features and immunophenotype of 9 cases of DNT were analyzed. RESULTS: The age of patients ranged from 12 to 51 years (mean age = 32 years). Most presented with partial seizures, sometimes accompanied by transient aphasia, agraphia and decreased visual acuity. One case was asymptomatic and discovered incidentally during a routine check-up. All patients had no neurological deficit found on physical examination. All tumors were located in the supratentorial cerebral cortex. There was no peritumoral edema or space-occupying effect on radiologic examination. The tumors involved either frontal lobe (number = 4), temporal lobe (number = 4), frontoparietal lobe (number = 1) . Two cases showed cystic changes. Two histologic variants of DNT were recognized: simple (number = 3) and complex (number = 6). Simple variant was composed mainly of the glioneuronal element, accompanied by surrounding oligodendrocyte-like cells, and the complex variant contained a low-grade glioma component, in addition to the glioneuronal element and sometimes foci of cortical dysplasia. CONCLUSIONS:
DNT is a benign tumor with excellent prognosis after surgical excision. Local recurrence is rare. Complex variant of DNT needs to be distinguished from other types of low-grade glioma.
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Authors | Fu-lin Wang, Xiang-hang Li, Qiu-ping Gui, Lin Liu |
Journal | Zhonghua bing li xue za zhi = Chinese journal of pathology
(Zhonghua Bing Li Xue Za Zhi)
Vol. 34
Issue 9
Pg. 566-8
(Sep 2005)
ISSN: 0529-5807 [Print] China |
PMID | 16468306
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Neurofilament Proteins
- S100 Proteins
- Synaptophysin
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Topics |
- Adolescent
- Adult
- Brain Neoplasms
(complications, metabolism, pathology, surgery)
- Cerebral Cortex
(metabolism, pathology)
- Child
- Child, Preschool
- Epilepsies, Partial
(etiology, metabolism, pathology, surgery)
- Female
- Follow-Up Studies
- Humans
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Neuroectodermal Tumors, Primitive
(complications, metabolism, pathology, surgery)
- Neurofilament Proteins
(metabolism)
- Oligodendroglia
(pathology, ultrastructure)
- S100 Proteins
(metabolism)
- Survival Rate
- Synaptophysin
(metabolism)
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