Nm 283, an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine.

Abstract

In order to improve the oral bioavailability of 2-C-methylcytidine, a potent anti-HCV agent, the corresponding 3'-O-L-valinyl ester derivative (NM 283) has been synthesized Based on its ease of synthesis and its physicochemical properties, NM 283 has emerged as a promising antiviral drug for treatment of chronic HCV infection.

• Authors: C Pierra, S Benzaria, A Amador, A Moussa, S Mathieu, R Storer, G Gosselin
• Journal: Nucleosides, nucleotides & nucleic acids (Nucleosides Nucleotides Nucleic Acids) Vol. 24 Issue 5-7 Pg. 767-70 ( 2005) ISSN: 1525-7770 [Print] United States
• PMID: 16248033 (Publication Type: Journal Article)

Chemical References

• Antiviral Agents
• Prodrugs
• Pyrimidine Nucleosides
• Deoxycytidine
• valopicitabine

Topics

• Animals
• Antiviral Agents (chemical synthesis, pharmacology)
• Chemistry, Pharmaceutical (methods)
• Deoxycytidine (chemistry, pharmacology)
• Drug Design
• Hepacivirus (genetics)
• Hepatitis C (drug therapy, virology)
• Humans
• Models, Chemical
• Prodrugs (chemistry, pharmacology)
• Pyrimidine Nucleosides (chemical synthesis, pharmacology)