A new cytotoxic daphnane diterpenoid, rediocide G, from Trigonostemon reidioides.

Abstract

Rediocide G (7), a new daphnane diterpenoid, was isolated from the roots of Trigonostemon reidioides (Euphorbiaceae), together with two congeners, rediocide A and rediocide B, (+)-syringaresinol, scopoletin, tomentin and stigmasterol. The structure of the new natural product was elucidated by comparison of its NMR and mass spectral data with those of previously known rediocides and confirmed by extensive 2D NMR spectral analysis. Rediocide G (7) was found to be cytotoxic to various cancer cell lines.

• Authors: Atchara Tempeam, Nopporn Thasana, Chitkavee Pavaro, Wongsatit Chuakul, Pongpun Siripong, Somsak Ruchirawat
• Journal: Chemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 53 Issue 10 Pg. 1321-3 (Oct 2005) ISSN: 0009-2363 [Print] Japan
• PMID: 16204992 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carbon Isotopes
• Diterpenes
• Macrolides
• Protons
• rediocide A
• rediocide G

Topics

• Carbon Isotopes
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Diterpenes (chemistry, isolation & purification, pharmacology)
• Drug Screening Assays, Antitumor
• Euphorbiaceae (chemistry, classification)
• HeLa Cells
• Humans
• KB Cells
• Macrolides
• Magnetic Resonance Spectroscopy (methods, standards)
• Molecular Conformation
• Plant Roots (chemistry)
• Protons
• Reference Standards
• Stereoisomerism