Abstract |
Highly oncogenic human papillomavirus (HPV) 16 and 18 variants might be expected to be particularly aggressive in HIV-positive women. The association of HPV16 and 18 variant lineages with race, human immunodeficiency virus ( HIV) coinfection, CD4+ T-cell count, HIV- RNA level, time-to-clearance of HPV infection and presence of squamous intraepithelial lesions (SIL) among women in the Women's Interagency HIV Study was studied. Subjects were followed semi-annually with Pap smear and cervicovaginal lavage (CVL). HPV DNA was detected in CVLs using MY09/11 L1 PCR assay. Specimens positive for HPV16/18 underwent E6 PCR and sequencing to determine the variant present. Specimens from 195 HPV16- and 162 HPV18-positive women were classified into variant lineages based on sequencing results. African variants of HPV16 and HPV18 were significantly more prevalent among African-Americans than among Caucasians [42 versus 14 % (P=0.001) and 60 versus 13 % (P<0.001), respectively]. However, it was not possible to detect associations between the HPV16 or 18 variant lineages and other factors studied. African variants of HPV16/18 were more common in women of African descent living outside Africa, which could reflect mixing behaviours and/or immunogenetic factors. However, in a large population of HIV-infected women, the variant of HPV16 or 18 was unrelated to persistence of infection or presence of SIL. If non-European variants are more oncogenic, the effect may involve a late stage in cervical tumorigenesis.
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Authors | Nicolas F Schlecht, Robert D Burk, Joel M Palefsky, Howard Minkoff, Xiaonan Xue, L Stewart Massad, Melanie Bacon, Alexandra M Levine, Kathryn Anastos, Stephen J Gange, D Heather Watts, Maria M Da Costa, Zigui Chen, Ji Yon Bang, Melissa Fazzari, Charles Hall, Howard D Strickler |
Journal | The Journal of general virology
(J Gen Virol)
Vol. 86
Issue Pt 10
Pg. 2709-2720
(Oct 2005)
ISSN: 0022-1317 [Print] England |
PMID | 16186224
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- AIDS-Related Opportunistic Infections
(virology)
- Adult
- Aged
- Cohort Studies
- DNA, Viral
(analysis)
- Female
- Genetic Variation
- HIV
(genetics)
- HIV Seropositivity
(complications, immunology)
- Humans
- Middle Aged
- Papillomaviridae
(genetics, physiology)
- Papillomavirus Infections
(complications, diagnosis, epidemiology)
- Prospective Studies
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