Ticlopidine: a new platelet aggregation inhibitor.

Abstract

The chemistry, pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage of ticlopidine are reviewed. Ticlopidine appears to inhibit platelet aggregation induced by adenosine diphosphate. Ticlopidine hydrochloride is rapidly absorbed after oral administration, and maximum antiplatelet effects occur one to three hours after the dose. In multicenter, randomized, double-blind trials, ticlopidine was more effective than aspirin or placebo in preventing stroke, myocardial infarction, or death caused by vascular events. Ticlopidine was more effective than aspirin in preventing recurrent transient ischemic attacks after six months of therapy. Ticlopidine has also been used to prevent occlusion and improve patency of aortocoronary bypass grafts, to prevent ischemic ulcers in patients with chronic arterial occlusive disease, and to slow the progression of diabetic microangiopathy. The most serious adverse effect, neutropenia, occurred in about 1% of patients. The most frequently reported adverse effects are diarrhea, nausea, vomiting, and abdominal cramps. Ticlopidine is indicated for reducing the risk of thrombotic stroke in patients who have experienced a minor stroke, transient ischemic attack, or completed thrombotic stroke. The recommended dosage is 500 mg/day in two divided doses taken with food. Ticlopidine is an alternative agent for the primary and secondary prevention of stroke. Because of the risk of neutropenia and agranulocytosis and the high cost of therapy, ticlopidine should be reserved for patients who are intolerant of or lack benefit from aspirin.

• Authors: M K Ito, A R Smith, M L Lee
• Journal: Clinical pharmacy (Clin Pharm) Vol. 11 Issue 7 Pg. 603-17 (Jul 1992) ISSN: 0278-2677 [Print] United States
• PMID: 1617911 (Publication Type: Clinical Trial, Journal Article, Review)

Chemical References

• Platelet Aggregation Inhibitors
• Ticlopidine

Topics

• Animals
• Drug Interactions
• Humans
• Platelet Aggregation Inhibitors (adverse effects, pharmacology, therapeutic use)
• Ticlopidine (adverse effects, pharmacology, therapeutic use)