Abstract |
99mTc-labeled 1-thio-beta-D-glucose (99mTc-1-TG) was synthesized under different ligand concentrations. 1-Thio-beta-D-glucose (1-TG) showed different chemical properties and higher stability at acid pH as compared to neutral and basic pH. Under different ligand concentrations, 99mTc-1-TG was obtained with high labeling efficiency of >97%, but the HPLC chromatogram varied with the ligand concentration. The results of a tumor cell uptake assay also depended on the ligand concentration. With the lowest ligand concentration tested (0.5 mg/ml of 1-TG), we obtained the highest uptake. With different glucose and insulin concentrations, 99mTc-1-TG uptake was not significantly different from that of [18F]FDG.
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Authors | Seung Jun Oh, Jin-Sook Ryu, Eun-Jin Yoon, Mun Sun Bae, Sun Joo Choi, Kyung Bae Park, Dae Hyuk Moon |
Journal | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
(Appl Radiat Isot)
Vol. 64
Issue 2
Pg. 207-15
(Feb 2006)
ISSN: 0969-8043 [Print] England |
PMID | 16168660
(Publication Type: Journal Article)
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Chemical References |
- Radiopharmaceuticals
- Technetium
- 1-thioglucose
- Glucose
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Topics |
- Brain Neoplasms
(diagnostic imaging, metabolism)
- Cell Line, Tumor
- Chromatography, High Pressure Liquid
- Colorectal Neoplasms
(diagnostic imaging, metabolism)
- Glucose
(analogs & derivatives, chemistry, pharmacokinetics)
- Humans
- Hydrogen-Ion Concentration
- Isotope Labeling
(methods)
- Lung Neoplasms
(diagnostic imaging, metabolism)
- Radionuclide Imaging
- Radiopharmaceuticals
(chemical synthesis, pharmacokinetics)
- Technetium
(chemistry)
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