[Association of two exonic genetic polymorphisms in the DNA repair gene XPC with risk of lung cancer in Chinese population].

Abstract

OBJECTIVE:

To explore the relationship between two exonic polymorphisms of DNA repair gene XPC and the susceptibility to lung cancer.

METHODS:

Genotypes were determined by the primer introduced restriction analysis-PCR(PIRA-PCR) and the PCR-restriction fragment length polymorphism(PCR-RFLP) approaches, respectively, in 320 histologically-confirmed lung cancer cases and 322 age and sex frequency-matched cancer-free controls.

RESULTS:

Multivariate logistic regression analysis revealed that individuals carrying at least one 499Val variant allele (Ala/Val + Val/Val genotypes) had a significantly increased risk for lung cancer (adjusted OR=1.54; 95%CI: 1.11-2.14), compared with the wild-type genotype (499Ala/Ala). Furthermore, individuals with both putative risk genotypes had a significantly higher risk (adjusted OR=2.55; 95%CI: 1.45-4.52), compared with those with both wild-genotypes. In addition, a potential super multiplicative gene-environment interaction between Ala499Val genotypes and smoking on lung cancer risk was unveiled. The odds ratios of lung cancer for individuals with both putative risk genotypes were 2.63 (95%CI=1.23-5.62) in nonsmokers and 7.36 (95%CI=3.19-17.0) in smokers, respectively.

CONCLUSION:

These findings support the hypothesis that these two XPC variants may contribute to the risk of developing lung cancer.

• Authors: Zhi-bin Hu, Yong-gang Wang, Hong-xia Ma, Wen Tan, Ju-yin Niu, Dong-xin Lin, Hong-bing Shen
• Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics (Zhonghua Yi Xue Yi Chuan Xue Za Zhi) Vol. 22 Issue 4 Pg. 415-8 (Aug 2005) ISSN: 1003-9406 [Print] China
• PMID: 16086280 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA-Binding Proteins
• XPC protein, human

Topics

• Asian People (genetics)
• China
• DNA-Binding Proteins (genetics)
• Exons (genetics)
• Female
• Genetic Predisposition to Disease (genetics)
• Genotype
• Humans
• Lung Neoplasms (ethnology, genetics)
• Male
• Middle Aged
• Polymerase Chain Reaction
• Polymorphism, Restriction Fragment Length
• Polymorphism, Single Nucleotide
• Risk Factors