Abstract |
The current study was carried out to examine the clinical characteristics and survival-probability rates of 51 patients treated for oral ( tongue) cancer and to correlate it with various tumor markers. The clinical data and survival probability rates were correlated with the immunohistological analysis of p27, Skp2, p53, Bcl-2, TUNEL (apoptotic rate) and c-erbB-2 markers. The 5-year survival-probability correlated with staging, grading and base of tongue location. An inverse relation between the expression of p27 and Skp2, p27 and grading, and a direct relation between Skp2 and grading were demonstrated. Concomitantly, significant correlations between low p27, high Skp2 and high TUNEL (apoptotic rate) expressions and between low p27 and high c-erbB-2 (Her2) expressions in the cancer lesions were demonstrated. The accumulated data may be employed in the future for a better understanding of the biology behind oral cancer and for developing better means of detection and treatment.
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Authors | Ofer Ben-Izhak, Fares Kablan, Zvi Laster, Rafael M Nagler |
Journal | Oral oncology
(Oral Oncol)
Vol. 41
Issue 8
Pg. 851-60
(Sep 2005)
ISSN: 1368-8375 [Print] England |
PMID | 16043384
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- S-Phase Kinase-Associated Proteins
- Tumor Suppressor Protein p53
- Ubiquitin
- Cyclin-Dependent Kinase Inhibitor p27
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(metabolism)
- Carcinoma, Squamous Cell
(diagnosis, genetics, metabolism)
- Cyclin-Dependent Kinase Inhibitor p27
(metabolism)
- Female
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- S-Phase Kinase-Associated Proteins
(metabolism)
- Survival Analysis
- Tongue Neoplasms
(diagnosis, genetics, metabolism)
- Tumor Suppressor Protein p53
(metabolism)
- Ubiquitin
(metabolism)
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