Abstract | CONTEXT: OBJECTIVE: The objective of this study was to compare the effects of isocaloric test meals with differing protein to fat ratios on fasting and postprandial ghrelin, insulin, glucose, appetite, and energy expenditure before and after weight loss on the respective dietary patterns. DESIGN: The study design was a randomized parallel design of 12 wk of weight loss (6 MJ/d) and 4 wk of weight maintenance (7.3 MJ/d) with meals administered at wk 0 and 16. SETTING: The study was performed at an out-patient research clinic. PATIENTS AND OTHER PARTICIPANTS: Fifty-seven overweight (body mass index, 33.8 +/- 3.5 kg/m2) hyperinsulinemic men (n = 25) and women (n = 32) were studied. INTERVENTIONS: MAIN OUTCOME MEASURES: RESULTS:
Weight loss (9.2 +/- 0.7 kg) and improvements in fasting and postprandial insulin and glucose occurred independently of diet composition. At wk 0 and 16, subjects wanted less to eat after the high- protein/low-fat than the standard protein/high-fat meal (P = 0.02). Fasting ghrelin increased (157.5 +/- 3.4 pg/ml or 46.6 +/- 1.0 pmol/liter; P < 0.001), and the postprandial ghrelin response improved with weight loss (P = 0.043) independently of diet composition. Postprandial hunger decreased with weight loss (P = 0.018) and was predicted by changes in fasting and postprandial ghrelin (r2 = 0.246; P = 0.004). Lean mass was the best predictor of fasting (r2 = 0.182; P = 0.003) and postprandial ghrelin (r2 = 0.096; P = 0.039) levels. CONCLUSIONS:
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Authors | Lisa J Moran, Natalie D Luscombe-Marsh, Manny Noakes, Gary A Wittert, Jennifer B Keogh, Peter M Clifton |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 90
Issue 9
Pg. 5205-11
(Sep 2005)
ISSN: 0021-972X [Print] United States |
PMID | 16014402
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Dietary Proteins
- Ghrelin
- Insulin
- Peptide Hormones
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Topics |
- Adult
- Blood Glucose
(metabolism)
- Body Composition
- Body Weight
- Dietary Proteins
(administration & dosage, therapeutic use)
- Energy Metabolism
- Fasting
(blood)
- Female
- Ghrelin
- Humans
- Hyperinsulinism
(blood, complications)
- Insulin
(blood)
- Male
- Middle Aged
- Obesity
(complications, diet therapy)
- Pain Measurement
- Peptide Hormones
(blood, metabolism)
- Postprandial Period
(physiology)
- Regression Analysis
- Satiation
(drug effects)
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