Abstract | RATIONALE: OBJECTIVES: METHODS: In connection with the rota-rod apparatus, the effects of acute administration of the adenosine receptor antagonists caffeine (non-selective), 8-cyclopentyl-1,3-dipropylxanthine ( DPCPX, adenosine A1 receptor antagonist) and 4-(2-[7-amino-2-{2-furyl}{1,2,4}triazolo-{2,3-a}{1,3,5}triazin-5-yl-amino]ethyl) phenol ( ZM241385, adenosine A2A receptor antagonist), together with R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine ( SCH23390, dopamine D1 receptor antagonist) and sulpiride ( dopamine D2 receptor antagonist), alone or in combination with ethanol (2.25 g/kg, i.p.), were studied. Twenty-four hours after, all animals were re-tested on the rota-rod after receiving the same dose of ethanol. RESULTS: The repeated administration of ethanol promoted a significant reduction of motor impairment on day 2 (i.e. rapid tolerance). This effect was blocked by caffeine (3.0-30.0 mg/kg, i.p.), DPCPX (3.0-6.0 mg/kg, i.p.) or SCH23390 (0.01-0.03 mg/kg, s.c.), but not with ZM241385 (0.5-1.0 mg/kg, i.p.) or sulpiride (1.0-3.0 mg/kg, i.p.). CONCLUSIONS:
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Authors | Luciano C Batista, Rui D S Prediger, Gina S Morato, Reinaldo N Takahashi |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 181
Issue 4
Pg. 714-21
(Oct 2005)
ISSN: 0033-3158 [Print] Germany |
PMID | 15983797
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Purinergic P1 Receptor Antagonists
- Receptors, Dopamine
- Ethanol
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Topics |
- Animals
- Brain
(drug effects)
- Drug Tolerance
- Ethanol
(pharmacology)
- Male
- Mice
- Purinergic P1 Receptor Antagonists
- Receptors, Dopamine
(drug effects)
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