FMH-induced decrease in central histamine levels produces increased feeding and body weight in rats.

Abstract

The present study tested the long-term effects of the histamine (H) synthesis inhibitor alpha-fluoromethylhistidine (FMH) on feeding and body weight in rats. FMH (administered via 2-week osmotic minipumps) increased feeding significantly throughout the test period. Body weights were also significantly increased toward the end of the test period. Hypothalamic H assays, performed at the end of the study, confirmed that FMH-treated rats had significantly lower H levels than controls. In general, the results suggest that H activity and feeding are inversely related.

• Authors: N Orthen-Gambill, M Salomon
• Journal: Physiology & behavior (Physiol Behav) Vol. 51 Issue 4 Pg. 891-3 (Apr 1992) ISSN: 0031-9384 [Print] United States
• PMID: 1594690 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Methylhistidines
• alpha-fluoromethylhistidine
• Histamine
• Histidine Decarboxylase

Topics

• Animals
• Body Weight (drug effects)
• Eating (drug effects)
• Histamine (metabolism)
• Histidine Decarboxylase (antagonists & inhibitors)
• Hypothalamus (drug effects)
• Male
• Methylhistidines (pharmacology)
• Rats
• Rats, Inbred Strains