Abstract |
Histone deacetylase inhibitors (HDACi) have been discovered as potential drugs for cancer treatment. The effect of BL1521, a novel HDACi, on the cell cycle distribution and the induction of apoptosis was investigated in a panel of MYCN single copy and MYCN amplified neuroblastoma cell lines. BL1521 arrested neuroblastoma cells in the G1 phase and induced up to 30% apoptosis. Downregulation of CDK4, upregulation of p21(WAF1/CIP1) and an increase of hypophosphorylated retinoblastoma protein were observed, indicating a possible mechanism for the cell-cycle arrest. BL1521 also induced downregulation of p27, which may underlie the observed induction of apoptosis.
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Authors | Krista Ouwehand, Annemieke J M de Ruijter, Chris van Bree, Huib N Caron, André B P van Kuilenburg |
Journal | FEBS letters
(FEBS Lett)
Vol. 579
Issue 6
Pg. 1523-8
(Feb 28 2005)
ISSN: 0014-5793 [Print] England |
PMID | 15733867
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- BL1521
- Cell Cycle Proteins
- Enzyme Inhibitors
- Histone Deacetylase Inhibitors
- Hydroxamic Acids
- Histone Deacetylases
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Topics |
- Cell Cycle Proteins
(metabolism)
- Cell Line, Tumor
- Cell Nucleus
(drug effects, metabolism)
- Cell Survival
(drug effects)
- Enzyme Inhibitors
(pharmacology)
- G1 Phase
(drug effects)
- Gene Expression Regulation, Neoplastic
- Histone Deacetylase Inhibitors
- Histone Deacetylases
(metabolism)
- Humans
- Hydroxamic Acids
(pharmacology)
- Neuroblastoma
(metabolism, pathology)
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