[Perivascular neoplasms of skin and soft tissues. A review].

Abstract

Perivascular neoplasms of skin and soft tissues comprise a group of benign and malignant mesenchymal neoplasms showing a perivascular myogenic differentiation. Whereas glomus tumour including its variants represents a clearly defined clinicopathological entity, the whole concept of haemangiopericytoma has been questioned in the last years, and no clear diagnostic criteria are established at the moment. Myopericytomas and myofibromas represent a morphological spectrum of perivascular spindle-shaped lesions. Infantile myofibroma/infantile myofibromatosis and solitary myofibroma of adults are characterized by a biphasic growth of mature, spindled, myofibroblastic cells and smaller, immature, mesenchymal cells associated with numerous haemangiopericytoma-like vessels. Benign and rare malignant myopericytomas of skin and soft tissues are characterized by a concentric, perivascular growth of plump spindled and round tumour cells staining positively for muscle actin, alpha-smooth muscle actin and more rarely for desmin. PEComas represent an enigmatic family of neoplasms composed of perivascular epithelioid, clear, and spindled tumour cells characterized by a coexpression of melanocytic and myogenic markers.

• Authors: T Mentzel
• Journal: Der Pathologe (Pathologe) Vol. 26 Issue 2 Pg. 134-45 (Mar 2005) ISSN: 0172-8113 [Print] Germany
• Vernacular Title: Perivaskuläre Tumoren der Haut und des Weichgewebes. Eine Ubersicht.
• PMID: 15657683 (Publication Type: English Abstract, Journal Article, Review)

Topics

• Diagnosis, Differential
• Fibroma (pathology)
• Humans
• Mesoderm (pathology)
• Neoplasms, Vascular Tissue (pathology)
• Skin Neoplasms (pathology)
• Soft Tissue Neoplasms (pathology)