Haem oxygenase-1: a target for dietary antioxidants.

Abstract

HO-1 (haem oxygenase-1) is a stress-response enzyme involved in the catabolism of haem. In animal models, it plays a key protective role in vascular disease. HO-1 has anti-inflammatory effects in macrophages and is induced by a range of stimuli, including antioxidants, in various cell types. As dietary antioxidants are considered to be beneficial in vascular disease, their protective effects may occur through induction of HO-1. Emerging evidence suggests that a range of dietary and other naturally occurring antioxidants stimulate HO-1 expression in various cell types, although regulation by these compounds has not been investigated in detail. These studies suggest that HO-1 may be a target for dietary therapy in vascular disease.

• Authors: R M Ogborne, S A Rushworth, C A Charalambos, M A O'Connell
• Journal: Biochemical Society transactions (Biochem Soc Trans) Vol. 32 Issue Pt 6 Pg. 1003-5 (Dec 2004) ISSN: 0300-5127 [Print] England
• PMID: 15506947 (Publication Type: Journal Article, Review)

Chemical References

• Antioxidants
• Membrane Proteins
• HMOX1 protein, human
• Heme Oxygenase (Decyclizing)
• Heme Oxygenase-1

Topics

• Antioxidants (pharmacology)
• Arteriosclerosis (physiopathology)
• Diet
• Enzyme Induction
• Heme Oxygenase (Decyclizing) (genetics, metabolism)
• Heme Oxygenase-1
• Humans
• Membrane Proteins
• Transcription, Genetic
• Vascular Diseases (physiopathology)