Abstract |
The purpose of this study was to investigate the in vitro antiviral properties of pterocarnin A, extracted from the bark of Pterocarya stenoptera (Juylandaceae). Results showed that pterocarnin A exhibited anti-herpes simplex virus (HSV) activity. It had a low selectivity index (SI) value and only possessed some level of cell cytotoxic effect at high antiviral concentrations. Mechanism studies demonstrated that pterocarnin A inhibited herpes simplex virus type 2 (HSV-2) from attaching and penetrating into cells. It also actively suppressed HSV-2 multiplication in Vero cells even when added 12 h after infection. This observation indicated that pterocarnin A affected the late stage(s) of HSV-2 infection cycle. Pterocarnin A also significantly reduced viral infectivity at high concentrations. From these observations, it was concluded that pterocarnin A suppressed both early and late in the replication cycle of HSV-2. The various modes of action of pterocarnin A in interfering with certain steps of viral infection thus merit further investigation.
|
Authors | Hua-Yew Cheng, Ta-Chen Lin, Chien-Min Yang, Kuo-Chih Wang, Chun-Ching Lin |
Journal | Microbes and infection
(Microbes Infect)
Vol. 6
Issue 8
Pg. 738-44
(Jul 2004)
ISSN: 1286-4579 [Print] France |
PMID | 15207820
(Publication Type: Journal Article)
|
Chemical References |
- Antiviral Agents
- Glycosides
- Plant Extracts
- pterocarnin A
- Gallic Acid
|
Topics |
- Animals
- Antiviral Agents
(pharmacology)
- Chlorocebus aethiops
- Gallic Acid
(analogs & derivatives, pharmacology, toxicity)
- Glycosides
(pharmacology, toxicity)
- Herpesvirus 2, Human
(drug effects, physiology)
- Juglandaceae
(chemistry)
- Plant Bark
(chemistry)
- Plant Extracts
(pharmacology, toxicity)
- Vero Cells
- Virus Inactivation
- Virus Replication
(drug effects)
|