A pancreatic-polypeptide-producing tumour associated with the WDHA syndrome.

Abstract

A case with the clinical appearance of WDHA syndrome is described in which serum concentrations of the newly recognized hormonal principle pancreatic polypeptide (PP) were highly elevated, while plasma levels of vasoactive intestinal peptide were within the normal range. The symptoms of the patient seem to be derived from the high levels of circulating PP, as illustrated by an improvement after resection of liver metastases accompanied by a marked decrease of serum PP concentration. Streptozotocin treatment was without effect upon the watery diarrhoea, and PP levels also remained unchanged during medical treatment. The appearance of a PP-secreting tumour leading to a clinical WDHA syndrome widens the spectrum of hormone assays that have to be performed in these patients.

• Authors: G Lundqvist, U Krause, L I Larsson, L Grimelius, O B Schaffalitzky de Muckadell, J Fahrenkrug, M Johnson, R E Chance
• Journal: Scandinavian journal of gastroenterology (Scand J Gastroenterol) Vol. 13 Issue 6 Pg. 715-8 ( 1978) ISSN: 0036-5521 [Print] England
• PMID: 151327 (Publication Type: Case Reports, Journal Article)

Chemical References

• Gastrins
• Vasoactive Intestinal Peptide
• Pancreatic Polypeptide
• Streptozocin

Topics

• Adult
• Body Water
• Diarrhea (blood, drug therapy, etiology)
• Female
• Gastrins (blood)
• Humans
• Pancreatic Neoplasms (blood, complications, metabolism)
• Pancreatic Polypeptide (blood, metabolism)
• Streptozocin (therapeutic use)
• Syndrome
• Vasoactive Intestinal Peptide (blood)