Abstract | BACKGROUND:
Nitric oxide (NO)- and prostacyclin-independent vasodilatation in several vascular beds has been linked to the activation of cytochrome P450 (CYP) epoxygenases expressed in endothelial cells. However, these enzymes, which generate vasodilator epoxyeicosatrienoic acids, may also produce oxygen-derived free radicals, which attenuate the bioavailability of NO. Here, we studied the involvement of CYP 2C9 in modulating endothelium-dependent and -independent changes in forearm blood flow (FBF) in healthy volunteers and in patients with manifest coronary artery disease. METHODS AND RESULTS: CONCLUSIONS:
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Authors | Stephan Fichtlscherer, Stefanie Dimmeler, Susanne Breuer, Rudi Busse, Andreas M Zeiher, Ingrid Fleming |
Journal | Circulation
(Circulation)
Vol. 109
Issue 2
Pg. 178-83
(Jan 20 2004)
ISSN: 1524-4539 [Electronic] United States |
PMID | 14662709
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Proteins
- Enzyme Inhibitors
- Vasodilator Agents
- Sulfaphenazole
- omega-N-Methylarginine
- Nitric Oxide
- CYP2C9 protein, human
- Cytochrome P-450 CYP2C9
- Aryl Hydrocarbon Hydroxylases
- Acetylcholine
- Ascorbic Acid
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Topics |
- Acetylcholine
(pharmacology)
- Adult
- Aryl Hydrocarbon Hydroxylases
(antagonists & inhibitors)
- Ascorbic Acid
(pharmacology)
- Blood Proteins
(metabolism)
- Coronary Artery Disease
(diagnosis, physiopathology)
- Cytochrome P-450 CYP2C9
- Endothelium, Vascular
(physiopathology)
- Enzyme Inhibitors
(pharmacology)
- Forearm
(blood supply)
- Humans
- Male
- Middle Aged
- Nitric Oxide
(metabolism)
- Oxidation-Reduction
(drug effects)
- Regional Blood Flow
(drug effects)
- Sulfaphenazole
(pharmacology)
- Vasodilation
(drug effects)
- Vasodilator Agents
(pharmacology)
- omega-N-Methylarginine
(pharmacology)
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