Abstract | BACKGROUND & OBJECTIVES: METHODS: Twenty three HIV seronegative women enrolled in the study were given Today pessarys containing 5 per cent of nonoxynol-9 for vaginal use at bedtime for 14 days. Colposcopy was done at enrollment and on day 14 and speculum examination on day 7 to assess the local toxicity. RESULTS: Most of the women (16/23, 69.6%) did not experience any symptoms of genital irritation. The remaining 7 (30.4%, 95% CI 11.6-49.2) women reported 11 episodes of mild irritative symptoms of short duration. On clinical examination, three adverse events were reported of which one could have been product related. Eight (34.8%) women showed willingness to use the product for protection against HIV transmission if it was approved. INTERPRETATION & CONCLUSION:
Nonoxynol-9 vaginal pessary was found to be safe and acceptable in once daily dose in low risk women after consecutive use for 14 days. Willingness for future use, if found safe and effective for HIV prevention was shown by 8 (34.8%) women.
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Authors | S Joshi, N Joglekar, M Ghate, J Unni, A Risbud, M Bentley, M Shepherd, R Bollinger, S Mehendale |
Journal | The Indian journal of medical research
(Indian J Med Res)
Vol. 117
Pg. 152-7
(Apr 2003)
ISSN: 0971-5916 [Print] India |
PMID | 14604303
(Publication Type: Clinical Trial, Clinical Trial, Phase I, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Anti-Infective Agents
- Nonoxynol
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Topics |
- Administration, Intravaginal
- Anti-Infective Agents
(administration & dosage, therapeutic use)
- Colposcopy
- Female
- HIV Infections
(prevention & control)
- HIV Seronegativity
- Humans
- India
- Nonoxynol
(administration & dosage, adverse effects, therapeutic use)
- Pessaries
- Risk Factors
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