Deaza- and deoxyadenosine derivatives: synthesis and inhibition of animal viruses as human infection models.

Abstract

N6-Cycloalkyl-2',3'-dideoxyadenosine derivatives and (2-chloro)-N6-cycloheptyl-3-deazaadenosine have been synthesized and tested, along with other (deaza)purine (deoxy)nucleosides from our chemical library, as inhibitors of virus replication against Bovine Herpes Virus 1 (BHV-1) and sheep Maedi/Visna Virus (MVV). Most compounds demonstrated good antireplicative activity against MVV, showing also low cell toxicity.

• Authors: Sauro Vittori, Daniela Salvatori, Rosaria Volpini, Silvia Vincenzetti, Alberto Vita, Sara Taffi, Stefano Costanzi, Catia Lambertucci, Gloria Cristalli
• Journal: Nucleosides, nucleotides & nucleic acids (Nucleosides Nucleotides Nucleic Acids) 2003 May-Aug Vol. 22 Issue 5-8 Pg. 877-81 ISSN: 1525-7770 [Print] United States
• PMID: 14565301 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antiviral Agents
• Deoxyadenosines
• Tubercidin

Topics

• Animals
• Antiviral Agents (chemical synthesis, pharmacology)
• Cattle
• Cell Survival (drug effects)
• Deoxyadenosines (chemical synthesis, pharmacology)
• Disease Models, Animal
• Herpesvirus 1, Bovine (drug effects)
• Humans
• Models, Molecular
• Molecular Structure
• Sheep
• Tubercidin (analogs & derivatives, chemical synthesis, pharmacology)
• Virus Diseases (drug therapy)
• Virus Replication (drug effects)
• Visna-maedi virus (drug effects)