No association between RFLPs at the porphobilinogen deaminase gene and schizophrenia.

Abstract

An association study of restriction fragment length polymorphisms (RFLPs) in the porphobilinogen deaminase (PBGD) gene and schizophrenia was conducted. RFLPs detected by MspI, PstI, ApaLI and BstNI in intron 1 of the gene were studied in 49 patients and 79 controls. There were no significant differences between the groups in allele frequencies, genotype counts or haplotype distribution.

• Authors: M J Owen, R Mant, E Parfitt, J Williams, P Asherson, G O'Mahoney, J Van Os, D Llewellyn, D Collier, M Gill
• Journal: Human genetics (Hum Genet) 1992 Sep-Oct Vol. 90 Issue 1-2 Pg. 131-2 ISSN: 0340-6717 [Print] Germany
• PMID: 1358782 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hydroxymethylbilane Synthase

Topics

• Adult
• Aged
• Aged, 80 and over
• Alleles
• Female
• Humans
• Hydroxymethylbilane Synthase (genetics)
• Introns (genetics)
• Male
• Middle Aged
• Polymorphism, Restriction Fragment Length
• Schizophrenia (enzymology, genetics)