Induction of anti-Escherichia coli activity in mice by phenothiazines, benzo[a]phenothiazines and benz[c]acridines.

Abstract

The abilities of 14 phenothiazines, 8 benzo[a]phenothiazines and 12 benz[c]acridines to induce anti-Escherichia coli activity in mice were compared. Pretreatment with several benzo[a]phenothiazines or benz[c]acridines protected mice from lethal infection of Escherichia coli in a dose-dependent manner, whereas most of the phenothiazines induced much weaker anti-Escherichia coli activity. However, direct contact of Escherichia coli with these compounds or their administration just after bacterial inoculation were ineffective. These data suggest the immunopotentiation activity of benzo[a]phenothiazines and benz[c]acridines.

• Authors: N Motohashi, H Sakagami, N Komatsu, M Fujimaki, C Wada, J Molnar
• Journal: In vivo (Athens, Greece) (In Vivo) 1992 Nov-Dec Vol. 6 Issue 6 Pg. 585-8 ISSN: 0258-851X [Print] Greece
• PMID: 1296806 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acridines
• Adjuvants, Immunologic
• Phenothiazines
• benz(c)acridine

Topics

• Acridines (pharmacology)
• Adjuvants, Immunologic (pharmacology)
• Animals
• Escherichia coli
• Escherichia coli Infections (immunology, prevention & control)
• Mice
• Mice, Inbred ICR (immunology)
• Phenothiazines (pharmacology)