Abstract | RATIONALE AND OBJECTIVES: METHODS: Twelve rabbits with VX2 carcinoma in the thigh underwent dynamic contrast-enhanced magnetic resonance (MR) imaging with gadopentetate dimeglumine and gadomer-17 at 24-hour intervals before (n = 12), 3 days (group 1, n = 12), 1 month (group 2, n = 8) and 2 months (group 3, n = 4) after 30 Gy irradiation. After taking postirradiation MR images, 4 rabbits were killed for histopathologic examination at each time interval. The enhancement characteristics in MR imaging and morphology of tumor vessels in histopathologic specimen were assessed. RESULTS: After gadopentetate dimeglumine injection, the enhancement characteristics were not different among tumors before and after irradiation (P > 0.05). For gadomer-17, the enhancement ratios decreased after irradiation. The shape of the curves for tumor enhancement before irradiation was significantly different from curves of group 1(P < 0.05). The specimens from group 3 showed sclerosis and wall thickening in arterioles. CONCLUSIONS: Dynamic contrast-enhanced MR imaging with a gadomer-17 reveals increased capillary permeability at an early phase after irradiation and chronic obliterating vasculopathy at delayed phase.
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Authors | Young Hoon Kim, Byung Ihn Choi, Woo Ho Cho, Sungjig Lim, Woo Kyoung Moon, Joon Koo Han, Hanns-Joachim Weinmann, Kee-Hyun Chang |
Journal | Investigative radiology
(Invest Radiol)
Vol. 38
Issue 9
Pg. 539-49
(Sep 2003)
ISSN: 0020-9996 [Print] United States |
PMID | 12960523
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Contrast Media
- gadomer 17
- Gadolinium
- Gadolinium DTPA
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Topics |
- Animals
- Capillary Permeability
(radiation effects)
- Contrast Media
- Gadolinium
- Gadolinium DTPA
- Magnetic Resonance Imaging
- Neoplasms, Experimental
(diagnosis, pathology)
- Rabbits
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