Abstract | BACKGROUND & OBJECTIVE: Abnormality of FHIT gene has been proved to be frequent in certain malignant tumors closely related to environmental oncogenic factors, such as lung cancer. Foreign scholars have begun to explore the relationship between FHIT gene and other tumor suppressor genes, which are implicated in the pathogenesis of lung cancer. This study was designed to investigate the relationship between hMSH(2) and FHIT protein expression and to explore the correlation of hMSH(2) and FHIT protein expression with clinicopathologic features of lung cancer. METHODS: Immunohistochemical analysis of hMSH(2) and FHIT protein expression in 40 lung cancer cases and 15 adjacent non- cancer lung tissues was performed; the positive rates of FHIT and hMSH(2) proteins were measured by image analysis system. RESULTS: CONCLUSION: FHIT gene may be a negative regulatory gene of hMSH(2) gene, and play an important role in the inactivation mechanism of hMSH(2) gene.
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Authors | Li-Qin Zhu, Lu-Ming Diao, De-Ji Chen, Hong-Gang Li, Xuan Liu, Zu-Yu Zou, Bei-Yun Li, Min Wang, Ming-Qiu Liu |
Journal | Ai zheng = Aizheng = Chinese journal of cancer
(Ai Zheng)
Vol. 22
Issue 6
Pg. 571-4
(Jun 2003)
China |
PMID | 12948402
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- DNA-Binding Proteins
- Neoplasm Proteins
- Proto-Oncogene Proteins
- fragile histidine triad protein
- Acid Anhydride Hydrolases
- MSH2 protein, human
- MutS Homolog 2 Protein
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Topics |
- Acid Anhydride Hydrolases
- Adult
- Aged
- Carcinoma, Non-Small-Cell Lung
(chemistry, pathology)
- DNA-Binding Proteins
- Female
- Gene Expression
- Humans
- Lung Neoplasms
(chemistry, pathology)
- Lymphatic Metastasis
- Male
- Middle Aged
- MutS Homolog 2 Protein
- Neoplasm Proteins
(analysis, genetics)
- Proto-Oncogene Proteins
(analysis, genetics)
- Smoking
(metabolism)
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