Abstract |
The present study was designed to investigate the effects of fermented miso in the diet on the development of lung tumors initiated by diisopropanolnitrosamine (BHP) in male Slc:Wistar rats. A total of 63 animals, 6 weeks of age, were divided into 4 groups and given BHP (2000 ppm) in their drinking water for 10 weeks. After the carcinogen treatment the rats were fed a normal control MF solid diet, or the same diet containing 10% long-term or short-term fermented miso for 12 weeks. The long-term fermented miso significantly reduced the number of lung tumors, adenocarcinomas and PCNA strongly positive tumors as compared with the short-term fermented miso. The present results thus indicate that dietary supplementation with long-term fermented miso could exert chemopreventive effects on lung carcinogenesis.
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Authors | Kateuhisa Shiraki, Kazunobu Une, Raita Yano, Satoko Otani, Akane Mimeoka, Hiromitsu Watanabe |
Journal | Hiroshima journal of medical sciences
(Hiroshima J Med Sci)
Vol. 52
Issue 1
Pg. 9-13
(Mar 2003)
ISSN: 0018-2052 [Print] Japan |
PMID | 12701648
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Nitrosamines
- diisopropanolnitrosamine
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Topics |
- Adenocarcinoma
(prevention & control)
- Animals
- Diet
- Fermentation
- Lung Neoplasms
(prevention & control)
- Male
- Nitrosamines
- Organ Size
- Rats
- Rats, Wistar
- Soybeans
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