Cytoprotective effect of piperine against benzo[a]pyrene induced lung cancer with reference to lipid peroxidation and antioxidant system in Swiss albino mice.

Abstract

The cytoprotective effect of piperine on benzo[a]pyrene (B[a]P) induced experimental lung cancer was investigated in male Swiss albino mice. Oral administration of piperine (100 mg/kg body wt.) effectively suppressed lung cancer initiated with B[a]P as revealed by the decrease in the extent of lipid peroxidation with concomitant increase in the activities of enzymatic antioxidants (superoxide dismutase, catalase and glutathione peroxidase) and non-enzymatic antioxidant (reduced glutathione, vitamin E and vitamin C) levels when compared to lung cancer bearing animals. Our data suggest that piperine may extend its chemopreventive effect by modulating lipid peroxidation and augmenting antioxidant defense system.

• Authors: K Selvendiran, J Prince Vijeya Singh, K Baba Krishnan, D Sakthisekaran
• Journal: Fitoterapia (Fitoterapia) Vol. 74 Issue 1-2 Pg. 109-15 (Feb 2003) ISSN: 0367-326X [Print] Netherlands
• PMID: 12628402 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Alkaloids
• Antioxidants
• Benzodioxoles
• Piperidines
• Polyunsaturated Alkamides
• Benzo(a)pyrene
• piperine

Topics

• Administration, Oral
• Alkaloids
• Animals
• Antioxidants (administration & dosage, pharmacology, therapeutic use)
• Benzo(a)pyrene
• Benzodioxoles
• Cytoprotection
• Lipid Peroxidation (drug effects)
• Lung (drug effects, enzymology, metabolism)
• Lung Neoplasms (chemically induced, prevention & control)
• Male
• Mice
• Phytotherapy
• Piperidines (administration & dosage, pharmacology, therapeutic use)
• Polyunsaturated Alkamides