Nodal CD8 positive cytotoxic T-cell lymphoma: a distinct clinicopathological entity.

Abstract	We studied 11 cases of nodal cytotoxic T-cell lymphoma, which express the CD8+ phenotype and cytotoxic molecules (T-cell intracellular antigen-1, granzyme B and perforin), to characterize the clinicopathologic spectrum of these neoplasms. The 11 cases consisted of four men and seven women, aged 5 to 82 years (mean, 53 years). All cases were nodal, and eight of 11 had extranodal involvement, the most common being in bone marrow (eight cases) and liver (six cases). The expression of these cytotoxic molecules has been reported in some T/natural killer cell lymphomas mostly involved in extranodal sites of skin, nasopharyngeal region, or gastrointestinal tracts, but these types of extranodal involvement were rare in our cases. Morphologically these lymphomas could be divided into two groups. One group (n = 6) showed a diffuse large cell type and massive necrosis or apoptosis that was accompanied by disseminated intravascular coagulation (DIC) or hemophagocytic syndrome (HPS) on the initial. The prognosis of this group was generally poor (survival = 1-19 months, median = 5 mo), and four of these six cases were fulminant. The other group (n = 5) showed a diffuse medium or mixed cell type, and the prognosis was not so poor (median survival = 17 mo). Our results suggest that these nodal cytotoxic T-cell lymphomas originated from activated cytotoxic T-cells and were highly accompanied with DIC or HPS.
Authors	Harumi Y Mukai, Yuichi Hasegawa, Hiroshi Kojima, Yasushi Okoshi, Naoko Takei, Yoriko Yamashita, Toshiro Nagasawa, Naoyoshi Mori
Journal	Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc (Mod Pathol) Vol. 15 Issue 11 Pg. 1131-9 (Nov 2002) ISSN: 0893-3952 [Print] United States
PMID	12429791 (Publication Type: Journal Article)
Chemical References	CD3 Complex CD8 Antigens Membrane Glycoproteins Membrane Proteins Poly(A)-Binding Proteins Pore Forming Cytotoxic Proteins Proteins RNA-Binding Proteins T-Cell Intracellular Antigen-1 TIA1 protein, human Tumor Necrosis Factor-alpha Perforin Interferon-gamma GZMB protein, human Granzymes Serine Endopeptidases
Topics	Adult Aged Aged, 80 and over CD3 Complex (analysis) CD8 Antigens (analysis) Child, Preschool Enzyme-Linked Immunosorbent Assay Epstein-Barr Virus Infections (metabolism, pathology, virology) Female Granzymes Herpesvirus 4, Human (genetics) Humans Immunohistochemistry In Situ Hybridization Interferon-gamma (blood) Lymph Nodes (chemistry, pathology) Lymphoma, T-Cell (metabolism, pathology, virology) Male Membrane Glycoproteins (analysis) Membrane Proteins (analysis) Perforin Poly(A)-Binding Proteins Pore Forming Cytotoxic Proteins Proteins RNA-Binding Proteins (analysis) Serine Endopeptidases (analysis) T-Cell Intracellular Antigen-1 T-Lymphocytes, Cytotoxic (chemistry, pathology) Tumor Necrosis Factor-alpha (metabolism)

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