Abstract | BACKGROUND/AIMS: METHODOLOGY: RESULTS:
After treatment, reductions of rectal polyp size were observed in all patients. Numbers of the rectal polyps also decreased significantly after treatment (median, 1; range, 0 to 30) compared with those before treatment (median, 19; range, 4 to 78) (P = 0.023). However, Grade 4 anemia due to lower intestinal ulcers occurred in two patients. Moreover, one year after termination of the treatment, increase in the size and number of rectal polyps was observed in six patients. CONCLUSIONS: Because of incomplete efficacy and severe toxicity, general use of this treatment for familial adenomatous polyposis patients must be deemed inappropriate.
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Authors | Takayuki Akasu, Tadashi Yokoyama, Kenichi Sugihara, Shin Fujita, Yoshihiro Moriya, Tadao Kakizoe |
Journal | Hepato-gastroenterology
(Hepatogastroenterology)
2002 Sep-Oct
Vol. 49
Issue 47
Pg. 1259-61
ISSN: 0172-6390 [Print] Greece |
PMID | 12239919
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Delayed-Action Preparations
- Indomethacin
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Topics |
- Adenoma
(drug therapy)
- Adenomatous Polyposis Coli
(drug therapy)
- Adult
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage)
- Delayed-Action Preparations
- Female
- Humans
- Indomethacin
(administration & dosage)
- Male
- Neoplasms, Multiple Primary
(drug therapy)
- Pilot Projects
- Rectal Neoplasms
(drug therapy)
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