[Lethal arrhythmias--etiological view and therapeutic approach].

Abstract

Life threatening arrhythmias may cause sudden cardiac death and are divided into bradyarrhythmias and tachyarrhythmias. Most of lethal arrhythmias result from structural (fibrosis and scar due to ischemia) and functional(heart failure and autonomic nerve) abnormalities of the myocardium. But primary electrical diseases, which are caused by the abnormalities of the gene, may also develop lethal arrhythmias without such abnormalities. The treatment of lethal arrhythmias consists of pharmacologic, non-pharmacologic therapy and combination of those. Current meta-analysis have showed the efficacy of K channel blockers as an anti-arrhythmic drug for lethal tachyarrhythmias. Pacemaker therapy for brady-arrhythmia has been established as non-pharmacologic therapy. Additionally, radiofrequency catheter ablation is useful for some lethal arrhythmias but most case should be considered for implantation of ICD. Recently, upstream approach to arrhythmia has been emphasized and recognized as a preventive method for lethal arrhythmias.

• Authors: Takeshi Ueyama, Kohshiro Moritani, Akihiko Shimizu, Hiroyuki Kakugawa, Masunori Matsuzaki
• Journal: Nihon rinsho. Japanese journal of clinical medicine (Nihon Rinsho) Vol. 60 Issue 7 Pg. 1269-77 (Jul 2002) ISSN: 0047-1852 [Print] Japan
• PMID: 12136603 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Anti-Arrhythmia Agents
• Ion Channels
• Potassium Channel Blockers

Topics

• Anti-Arrhythmia Agents (therapeutic use)
• Autonomic Nervous System Diseases (complications)
• Bradycardia (etiology, therapy)
• Catheter Ablation
• Death, Sudden, Cardiac (etiology)
• Evidence-Based Medicine
• Humans
• Ion Channels (genetics)
• Meta-Analysis as Topic
• Myocardial Ischemia (complications)
• Potassium Channel Blockers (therapeutic use)
• Tachycardia (etiology, therapy)