Bupropion SR enhances weight loss: a 48-week double-blind, placebo- controlled trial.

Abstract

OBJECTIVE:

To critically examine the efficacy of bupropion SR for weight loss.

RESEARCH METHODS AND PROCEDURES:

This 24-week multicenter, double-blind, placebo-controlled study randomized obese adults to placebo, bupropion SR 300, or 400 mg/d. Subjects were counseled on energy-restricted diets, meal replacements, and exercise. During a 24-week extension, placebo subjects were randomized to bupropion SR 300 or 400 mg/d in a double-blinded manner.

RESULTS:

Of 327 subjects enrolled, 227 completed 24 weeks; 192 completed 48 weeks. Percentage losses of initial body weight for subjects completing 24 weeks were 5.0%, 7.2%, and 10.1% for placebo, bupropion SR 300, and 400 mg/d, respectively. Compared with placebo, net weight losses were 2.2% (p = 0.0468) and 5.1% (p < 0.0001) for bupropion SR 300 and 400 mg/d, respectively. The percentages of subjects who lost >or=5% of initial body weight were 46%, 59%, and 83% (p vs. placebo < 0.0001) for placebo, bupropion SR 300, and 400 mg/d, respectively; weight losses of >or=10% were 20%, 33%, and 46% (p vs. placebo = 0.0008) for placebo, bupropion SR 300, and 400 mg/d, respectively. Withdrawals, changes in pulse and blood pressure did not differ significantly from placebo at 24 weeks. Subjects who completed 48 weeks maintained mean losses of initial body weight of 7.5% and 8.6% for bupropion SR 300 and 400 mg/d, respectively.

DISCUSSION:

Bupropion SR 300 and 400 mg/d were well-tolerated by obese adults and were associated with a 24-week weight loss of 7.2% and 10.1% and sustained weight losses at 48 weeks.

• Authors: James W Anderson, Frank L Greenway, Ken Fujioka, Kishore M Gadde, James McKenney, Patrick M O'Neil
• Journal: Obesity research (Obes Res) Vol. 10 Issue 7 Pg. 633-41 (Jul 2002) ISSN: 1071-7323 [Print] United States
• PMID: 12105285 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Cholesterol, HDL
• Delayed-Action Preparations
• Placebos
• Bupropion

Topics

• Adolescent
• Adult
• Blood Glucose (analysis)
• Blood Pressure
• Body Constitution
• Bupropion (administration & dosage, therapeutic use)
• Cholesterol, HDL (blood)
• Delayed-Action Preparations
• Diet, Reducing
• Double-Blind Method
• Exercise
• Female
• Humans
• Male
• Middle Aged
• Obesity (drug therapy)
• Placebos
• Pulse
• Weight Loss