Abstract | BACKGROUND: OBSERVATIONS: The authors report herein the first five cases of drug-induced hypersensitivity syndrome due to fluindione. Clinical signs included erythroderma and severe systemic manifestations which occurred within 3 to 8 weeks after introducing the molecule. Sex ratio was four males for one female; their ages ranged from 53 to 84 years. Clinical signs included erythroderma (with photosensitivity in two patients), lymphadenopathy and fever evoking severe sepsis. In our observations, marked eosinophilia (5 cases), lymphocytosis, atypical lymphocytes (4 cases), hepatic cytolysis (4 cases), associated in 2 cases with hepatic cholestasis, and pulmonary signs were noted. Cutaneous eruption healed in about 3 to 6 weeks after withdrawal of the drug. In two cases, systemic steroids were required for the severity of systemic manifestations. Long after the acute episode and when steroids were stopped, patch testing with fluindione was still positive. DISCUSSION:
|
Authors | A Sparsa, C Bédane, H Benazahary, P De Vencay, M L Gauthier, V Le Brun, S Boulinguez, V Loustaud-Ratti, P Soria, E Vidal, J M Bonnetblanc |
Journal | Annales de dermatologie et de venereologie
(Ann Dermatol Venereol)
Vol. 128
Issue 10 Pt 1
Pg. 1014-8
(Oct 2001)
ISSN: 0151-9638 [Print] France |
Vernacular Title | Syndrome d'hypersensibilité médicamenteuse à la fluindione. |
PMID | 11907960
(Publication Type: Case Reports, English Abstract, Journal Article)
|
Chemical References |
- Anticoagulants
- Phenindione
- fluindione
|
Topics |
- Aged
- Aged, 80 and over
- Anticoagulants
(adverse effects)
- Drug Eruptions
(etiology)
- Female
- Humans
- Male
- Middle Aged
- Phenindione
(adverse effects, analogs & derivatives)
- Syndrome
|