[Cytotoxic natural killer/T-cell lymphomas of the lymph nodes].

Abstract

OBJECTIVE:

To investigate the clinicopathologic features of cytotoxic natural killer (NK)/T-cell lymphomas of the lymph nodes.

METHODS:

Clinicopathologic observations and follow up on 5 cases of cytotoxic NK/T-cell lymphomas of the lymph nodes, immunohistochemical staining for CD45RO, CD8, CD56, CD30, CD20, TIA-1 and in situ hybridization for EBER1/2 were performed.

RESULTS:

(1) The clinicopathologic features of cytotoxic NK-T-cell lymphomas of the lymph nodes were summarized; (2) The tumor cells were positive for CD45RO in 4 of the 5 cases, in which 3 cases were also positive for CD56. One case was of null cell type. The tumor cells were positive for TIA-1 and EBER1/2 in all 5 cases.

CONCLUSIONS:

The clinicopathological features and special immunophenotypes of cytotoxic NK/T-cell lymphomas of the lymph nodes were present in all 5 cases. Clinically, this entity tends to be an aggressive process with poor prognosis.

• Authors: T Lin, W Liu, G Li, F Li, J Yuan
• Journal: Zhonghua bing li xue za zhi = Chinese journal of pathology (Zhonghua Bing Li Xue Za Zhi) Vol. 30 Issue 2 Pg. 101-4 (Apr 2001) ISSN: 0529-5807 [Print] China
• PMID: 11866963 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• CD56 Antigen
• Epstein-Barr virus encoded RNA 1
• Poly(A)-Binding Proteins
• Proteins
• RNA, Viral
• RNA-Binding Proteins
• T-Cell Intracellular Antigen-1
• TIA1 protein, human
• Leukocyte Common Antigens

Topics

• Adult
• Aged
• CD56 Antigen (metabolism)
• Follow-Up Studies
• Herpesvirus 4, Human
• Humans
• Killer Cells, Natural (pathology)
• Leukocyte Common Antigens (metabolism)
• Lymph Nodes (metabolism, pathology)
• Lymphoma, T-Cell (metabolism, pathology, virology)
• Male
• Middle Aged
• Nose (pathology)
• Nose Neoplasms (metabolism, pathology, virology)
• Poly(A)-Binding Proteins
• Prognosis
• Proteins (metabolism)
• RNA, Viral (metabolism)
• RNA-Binding Proteins
• T-Cell Intracellular Antigen-1