Comparison of gadobenate dimeglumine and gadopentetate dimeglumine: a study of MR imaging and inductively coupled plasma atomic emission spectroscopy in rat brain tumors.

Abstract

BACKGROUND AND PURPOSE:

After the advent of extracellular contrast media, hepatobiliary-specific gadolinium chelates were developed to improve the diagnostic value of MR imaging of the liver. Gadobenate dimeglumine (Gd-BOPTA) is a new paramagnetic contrast agent with partial biliary excretion that produces prolonged enhancement of liver parenchyma on T1-weighted images. However, whether Gd-BOPTA is useful as a contrast agent in central nervous system disease, particularly in brain tumors, is unclear.

METHODS:

The behavior of Gd-BOPTA as a brain tumor-selective contrast agent was compared with that of gadopentetate dimeglumine (Gd-DTPA), an MR contrast agent used in central nervous system disease, in a common dose of 0.1 mmol/kg. An MR imaging study of these two contrast agents was performed, and tissue concentrations were measured with inductively coupled plasma atomic emission spectroscopy (ICP-AES).

RESULTS:

Gd-BOPTA showed better MR imaging enhancement in brain tumors than did Gd-DTPA at every time course until 2 hours after administration and no enhancement in peritumoral tissue and normal brain. Corresponding results with ICP-AES showed significantly greater uptake of Gd-BOPTA in tumor samples than that in peritumoral tissue and normal brain 5 minutes after administration. Gadolinium was retained for a longer time in brain tumors when Gd-BOPTA rather than Gd-DTPA was administered.

CONCLUSION:

Gd-BOPTA is a useful contrast agent for MR imaging in brain tumors and possibly an effective absorption agent for neutron capture therapy.

• Authors: Tian Zhang, Akira Matsumura, Tetsuya Yamamoto, Fumiyo Yoshida, Tadao Nose, Nobuhiro Shimojo
• Journal: AJNR. American journal of neuroradiology (AJNR Am J Neuroradiol) Vol. 23 Issue 1 Pg. 15-8 (Jan 2002) ISSN: 0195-6108 [Print] United States
• PMID: 11827870 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Contrast Media
• Organometallic Compounds
• gadobenic acid
• Meglumine
• Gadolinium DTPA

Topics

• Animals
• Brain (pathology)
• Brain Neoplasms (diagnosis)
• Contrast Media (pharmacokinetics)
• Gadolinium DTPA (pharmacokinetics)
• Glioma (diagnosis)
• Humans
• Image Enhancement
• Magnetic Resonance Imaging
• Male
• Meglumine (analogs & derivatives, pharmacokinetics)
• Metabolic Clearance Rate
• Organometallic Compounds (pharmacokinetics)
• Rats
• Rats, Inbred F344
• Spectrophotometry, Atomic