[A comparative clinical study of carboplatin solution and carboplatin powder].

Abstract

OBJECTIVE:

To observe the efficacy and side effects of carboplatin solution in comparison with carboplatin powder.

METHODS:

A multicenter, open randomized controlled trial was carried out. A total of 121 patients with small cell lung cancer (SCLC), non-small cell lung cancer (NSCLC) and breast cancer (BC) were randomized into carboplatin injection group (study group) and carboplatin powder group (control group), treated with CE, CIE and CAF protocol, respectively. The same drugs and dosage were used in the two groups.

RESULTS:

The response rate of the study group and the control group was 94% and 67% in SCLC (P > 0.05), 12% and 22% in NSCLC (P > 0.05) and 71.4% and 67% in BC (P > 0.05), respectively. The major side effects were myelosuppression and gastrointestinal reactions, the frequency and intensity of which were statistically not different in the 2 groups of patients.

CONCLUSION:

Carboplatin solution is as effective as carboplatin powder for the treatment of cancer.

• Authors: Q Li, J Zhou, F Qu
• Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] (Zhonghua Zhong Liu Za Zhi) Vol. 23 Issue 2 Pg. 170-2 (Mar 2001) ISSN: 0253-3766 [Print] China
• PMID: 11783029 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Antineoplastic Agents
• Powders
• Solutions
• Carboplatin

Topics

• Antineoplastic Agents (adverse effects, therapeutic use)
• Breast Neoplasms (drug therapy, pathology)
• Carboplatin (adverse effects, therapeutic use)
• Carcinoma, Non-Small-Cell Lung (drug therapy, pathology)
• Carcinoma, Small Cell (drug therapy, pathology)
• Gastrointestinal Diseases (chemically induced)
• Humans
• Leukopoiesis (drug effects)
• Lung Neoplasms (drug therapy, pathology)
• Neoplasms (drug therapy, pathology)
• Powders
• Solutions
• Treatment Outcome