[The study of nitric oxide synthase in ovary tumor].

Abstract

OBJECTIVE:

To study the activity of nitric oxide synthase (NOS) in ovarian tumors.

METHODS:

Spectrophotometry was used to examine NOS activity and NADPH-diaphorase histochemistry to identify its localization.

RESULTS:

The activity of NOS was significantly higher in malignant than in normal ovarian tissue and benign ovarian tumors (P < 0.01). There was negative correlation between NOS activity and tumor cell differentiation. NOS reaction product was mainly located in cancer cells, and was negative in the interstitial tissue. Furthermore, NOS was mostly located in membrane and cytoplasm of the cancer cell.

CONCLUSION:

Increase in nitric oxide synthase activity might be related to the growth and malignant behavior of ovarian cancer.

• Authors: Y Wu, Y Wang, H Song
• Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] (Zhonghua Zhong Liu Za Zhi) Vol. 22 Issue 1 Pg. 50-2 (Jan 2000) ISSN: 0253-3766 [Print] China
• PMID: 11776599 (Publication Type: English Abstract, Journal Article)

Chemical References

• Nitric Oxide Synthase

Topics

• Adolescent
• Adult
• Aged
• Cell Membrane (enzymology)
• Cytoplasm (enzymology)
• Female
• Humans
• Middle Aged
• Nitric Oxide Synthase (metabolism)
• Ovarian Neoplasms (enzymology)
• Theca Cells (enzymology)