Cancer chemoprevention by ginseng in mouse liver and other organs.

Abstract

Oral administration of red ginseng extracts (1% in diet for 40 weeks) resulted in the significant suppression of spontaneous liver tumor formation in C3H/He male mice. Average number of tumors per mouse in control group was 1.06, while that in red ginseng extracts-treated group was 0.33 (p<0.05). Incidence of liver tumor development was also lower in red ginseng extracts-treated group, although the difference from control group was not statistically significant. Anti-carcinogenic activity of white ginseng extracts, besides red ginseng extracts, was also investigated. In the present study, the administration of white ginseng extracts was proven to suppress tumor promoter-induced phenomena in vitro and in vivo. It is of interest that oral administration of the extracts of Ren-Shen-Yang- Rong-Tang, a white ginseng-containing Chinese medicinal prescription, resulted in the suppression of skin tumor promotion by 12-o-tetradecanoylphorbol-13-acetate in 7,12-dimethylbenz[a]anthracene-initiated CD-1 mice. These results suggest the usefulness of ginseng in the field of cancer prevention.

• Authors: H Nishino, H Tokuda, T Ii, M Takemura, M Kuchide, M Kanazawa, X Y Mou, P Bu, J Takayasu, M Onozuka, M Masuda, Y Satomi, T Konoshima, N Kishi, M Baba, Y Okada, T Okuyama
• Journal: Journal of Korean medical science (J Korean Med Sci) Vol. 16 Suppl Pg. S66-9 (Dec 2001) ISSN: 1011-8934 [Print] Korea (South)
• PMID: 11748379 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticarcinogenic Agents
• Plant Extracts

Topics

• Animals
• Anticarcinogenic Agents (pharmacology)
• Female
• Liver Neoplasms, Experimental (prevention & control)
• Male
• Mice
• Mice, Inbred C3H
• Panax
• Plant Extracts (pharmacology)
• Plant Roots
• Skin Neoplasms (prevention & control)