Clinical ergotism induced by ritonavir.

Abstract

Ritonavir strongly inhibits cytochrome P450, thus altering the metabolism of other drugs. We report on an HIV-positive man who, on his 13th day of ritonavir therapy, developed severe ergotism after self-administration of low doses of ergotamine. Drug interactions, the degree of responsibility of the patient and the availability of over-the-counter medications must be considered when prescribing antiretroviral therapy.

• Authors: A Vila, A Mykietiuk, P Bonvehì, E Temporiti, A Urueña, F Herrera
• Journal: Scandinavian journal of infectious diseases (Scand J Infect Dis) Vol. 33 Issue 10 Pg. 788-9 ( 2001) ISSN: 0036-5548 [Print] England
• PMID: 11728055 (Publication Type: Case Reports, Journal Article)

Chemical References

• Analgesics, Non-Narcotic
• HIV Protease Inhibitors
• Ritonavir
• Ergotamine

Topics

• Adult
• Analgesics, Non-Narcotic (adverse effects)
• Drug Interactions
• Drug Therapy, Combination
• Ergotamine (adverse effects)
• Ergotism (etiology)
• HIV Infections (drug therapy)
• HIV Protease Inhibitors (adverse effects)
• Humans
• Male
• Ritonavir (adverse effects)